Endocrine Abstracts

Introduction: Differentiated thyroid carcinoma is usually associated with a good prognosis. However, some of these tumors (5%) are radioiodine refractory and have different progression, associated with poor prognosis. In these situations, some tyrosine kinase inhibitors (TKI) can be used. We present a clinical case showing the difficulties in the follow-up and treatment of these patients.Clinical case: A 60 years old woman, with a “multicentric papi...

Introduction: Adrenocortical carcinoma (ACC) is a rare malignancy with high recurrence and poor prognosis. Lactate dehydrogenase (LDH) is an enzyme of the glycolytic pathway that is associated with tumour progression in several cancers. To date, evidence on the prognostic value of LDH in ACC is limited.Aims: To assess the impact of LDH in disease-free survival (DFS) in operated ACC.Materials and methods: Retrospective cohort study ...

Introduction: Congenital ichthyoses are a group of inherited keratinization disorders that pose a challenge in terms of diagnosis, treatment, and clinical associations with other pathologies. The association with vitamin D deficiency and possible bone changes is cited, but the exact mechanism of occurrence of endocrine pathologies is not described.Case report: We report the case of a 16-year-old teenage boy known to have congenital ichthyosis, having bee...

Introduction: Thyroid ultrasonography and fine needle aspiration (FNA) are the most useful techniques in the evaluation of thyroid nodules. They are cheap, fast, minimally invasive and high precision methods. The FNA can be performed by palpation or ultrasound guidance. The use of ultrasound reduces the nondiagnostic results rate. However, the cytologic diagnostic accuracy depends on the technique and pathologist experience. Ultrasonography confirms the presence of a thyroid n...

Introduction: Primary mitochondrial disease is a heterogeneous group of disorders of mitochondrial energy metabolism. Neuromuscular symptoms are the main features, but diabetes mellitus (DM) is present in many patients. DM is related to a deficient energy production, which leads to decreased insulin secretion and ultimately to β-cell apoptosis. In most cases, DM has an insidious onset with requirement of insulin 2-4 years after diagnosis. About 20% of cases present with a...

Introduction: The Flash glucose monitoring system (FGS) has recently received a licence for children and young people aged 4–17 years with Type 1 diabetes (T1D) in the United Kingdom. Although many families attending a single UK diabetes centre reporting utilising FGS even prior to its licence we aimed to assess the patient experience.Methods: Patients and families were invited to undertake a 14 day FGS trial following group introductory sessions. 8...

-Diana Borges Duarte and Francisca Puga are joint first authors and contributed equallyBackground: As therapeutic options improve for Cushing’s disease (CD), most patients can now achieve control or cure of hypercortisolism. However, persistent complaints are often reported. Evaluation of health-related quality of life (HR-QoL) can highlight impairments beyond the stricter clinical aspects. Our aim was to evaluate HR-QoL with a specific focus on men...

Maturation of the definitive adrenal cortex occurs between 3 and 6 weeks post-partum and involves onset of CYP11B2 expression and establishment of the laminin-encased 3D structure of glomeruli that contain rosettes of 10 to 15 zona glomerulosa (zG) cells that work in coordination to produce optimal amounts of aldosterone. Although this process is dependent on canonical WNT/b-catenin signaling, cellular sources of WNT ligands remain elusive and the mechanisms involved in the ex...

Background: Only a few cases of pituitary tumor swift from non-functioning to Cushing disease (CD) have been previously presented in the literature. The exact mechanism is still unknown. We present a case of a patient with a non-functioning pituitary adenoma, who developed CD from the residual tumor, 13 years after the initial diagnosis and following 2 surgical interventions and radiation therapy.Case presentation: A 51-year-old woman initially presented...

Abstract: Parathyroid gland adenoma is benign, PTH-secreting tumour, which leads to primary hyperparathyroidism. Congenital hyperparathyroidism may occur without any other symptoms, on it’s own, but often is part of MEN1 or MEN2 syndromes. PTH activates osteoclasts, that resorbs calcium from bone and brings calcium to blood serum. Also PTH also induces calcium reabsorption from kidney tubules band and blocks excretion of phosphates. Long time PTH secreting adenoma shows n...